Basic Research Publications
Published articles by Basic Research Department staff are listed below. Click on the link to review the Pubmed abstract or free full article where available.
LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress.
Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR.
Cell Stem Cell. 2011 Mar 4;8(3):267-80. PMID: 21362567 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/21362567
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease associated mutations and regulates cytoplasmic localisation.
Nichols RJ*, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott A, Alessi DR*. Biochem J. 2010 Jul 19. 430: 393-404 *indicates corresponding authors
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localisation.
Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR*, Nichols RJ*. Biochem J. 2010 Jul 21. 430: 405-413 *indicates corresponding authors
Can cellular models revolutionize drug discovery in Parkinson's disease?
Schüle B, Pera RA, Langston JW. Biochim Biophys Acta. 2009 Nov;1792(11):1043-51. Epub 2009 Sep 3. Review. PMID: 19733239 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/19733239
Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.
Manning-Boğ AB, Schüle B, Langston JW. Neurotoxicology. 2009 Nov;30(6):1127-32. Epub 2009 Jul 2. PMID: 19576930 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/19576930
Parkin gene variations and parkinsonism: association does not imply causation.
Langston JW, Tanner CM, Schüle B. Ann Neurol. 2007 Jan;61(1):4-6. No abstract available. PMID: 17262853 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/17262853
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.
Fuchs J, Nilsson C, Kachergus J, Munz M, Larsson EM, Schüle B, Langston JW, Middleton FA, Ross OA, Hulihan M, Gasser T, Farrer MJ. Neurology. 2007 Mar 20;68(12):916-22. Epub 2007 Jan 24. PMID: 17251522 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/17251522
Novel features in a patient homozygous for the L347P mutation in the PINK1 gene.
Doostzadeh J, Tetrud JW, Allen-Auerbach M, Langston JW, Schüle B. Mov Disord. Parkinsonism Relat Disord. 2007 Aug;13(6):359-61. Epub 2006 Oct 19. PMID: 17055324 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/17055324