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GI Natural History Study

Your Institute is currently conducting a research study called the GI Natural History Study to to discover more about how gastrointestinal symptoms affect Parkinson’s patients, how these symptoms change over time and how well different medications can help these symptoms.What is the gut important in Parkinson’s?

It is estimated that gastrointestinal dysfunction in Parkinson’s disease may occur in up to 80% of patients.  While we are beginning to understand that Parkinson’s disease pathology is not limited to the brain and that it is likely also causing gastrointestinal dysfunction, we currently do not have good methods to assess how troublesome a burden this dysfunction is, nor a way measure the benefit of treating gastrointestinal symptoms.  This study will characterize the natural progression of gastrointestinal symptoms in patients with Parkinson’s disease, or those who are at high risk for developing the motor symptoms of Parkinson’s disease.  It is hoped that this study may lead us to earlier diagnosis of Parkinson’s disease, improved patient care, as well as identifying new ways to test investigational drugs that may be neuroprotective and serve as future treatments for these symptoms.People with Parkinson’s disease, both with and without gastrointestinal problems are needed for this 2 year study. For more information, please contact the Parkinson’s Institute Clinical Trials team at (408) 542-5608 or by email at Trials@ThePI.org.

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