Left Menu Image
Marc Bolliger

Marc Bolliger, Ph.D.

Staff Scientist

PhD in Natural Sciences from Swiss Federal Institute of Technology Zurich (ETH)Diploma in Natural Sciences from Swiss Federal Institute of Technology Zurich (ETH)

I joined the Parkinson's Institute as a Staff Scientist in summer 2013. My projects focus on identifying the kinases and phosphatases that regulate LRRK2.

I earned my Ph.D. in biochemistry from ETH Zürich in 2001. Under the supervision of Dr. Sergio Gloor I discovered two neuroligin genes encoding cell adhesion proteins localized at the synapse. One of them, neuroligin 4, became the first gene shown to be implicated in autism. While working as a Postdoctoral Fellow in Dr. Peter Sonderegger's lab at University of Zürich, I investigated neurotrypsin, a neuronal protease associated with mental retardation. Based on the analysis of transgenic and knockout mice we succeeded in identifying the substrate of neurotrypsin, namely agrin, and a developmental analysis of these mice demonstrated that this proteolytic event regulates the maturation of the neuromuscular junction. Then I joined Dr. Thomas Südhof's lab at Stanford University to follow up on my graduate work. We identified a novel point mutation in neuroligin 4 in autistic patients and demonstrated that this mutation impairs protein folding. In addition, I screened for ligands of a brain-specific G-protein coupled receptor, and studied its signaling upon binding of these ligands.

Go Back | Send this page to a friend
2500 Hospital Drive, Bldg #10, Suite 1 | Mountain View, CA 94040
650.770.0201 main | 650.770.0204 fax (Clinic Secure)