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R. Jeremy Nichols

R. Jeremy Nichols,

Director of Signal Transduction and LRRK2 Biology

Jeremy Nichols, PhD obtained a BS degree with honors from Austin Peay State University where he was involved in field biology studies of reptile and amphibian populations. He then obtained a PhD in the laboratory of Paula Traktman, PhD at the Medical College of Wisconsin. While there, he studied a novel family of protein kinases called the vaccinia related kinases (VRKs) and found that they regulate a protein required for meiotic cell division. He also studied proteins involved in the infectious cycle of the small pox vaccine agent vaccinia virus, characterizing viral proteins involved in virion entry and virulence. He pursued his interest in cellular signaling with a post-doctoral fellowship at the United Kingdom Medical Research Council Protein Phosphorylation Unit in Dundee, Scotland with Professor Dario Alessi (FRSE, FRS). While there, he sought to unravel the role of LRRK2 in cells and how disease associated mutations cause Parkinson’s disease. He also successfully developed assays for LRRK2 both in vitro and in the cell. He joined The Parkinson’s Institute in 2010 where his LRRK2 investigations can gain greater impact by integration with the clinical resources and basic science research at The Parkinson’s Institute.

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